Heart Failure Journal Club Schedule (2005-2006)

Second Thursdays, 11:00 am – 12:30 pm
Room 116, SMI
Timothy J. Kamp, MD, Ph.D., Associate Professor, Medicine (CV), Chair
Contact info@cvrc.wisc.edu for further information

Fall 2005

Sep. 8, 2005
Timothy J. Kamp, MD, Ph.D. Associate Professor, Medicine (Cardiovascular)

Heterodimerization of b1- and b2-Adrenergic Receptor Subtypes Optimizes b-Adrenergic Modulation of Cardiac Contractility. Wei-Zhong Zhu, Khalid Chakir, Shengjun Zhang, Dongmei Yang, Catherine Lavoie, Michel Bouvier, Terence E. He´bert, Edward G. Lakatta, Heping Cheng, Rui-Ping Xiao. (Circ Res. 2005; 97:244-251.)

Crosstalk of b-Adrenergic Receptor Subtypes Through Gi Blunts b-Adrenergic Stimulation of L-Type Ca²⁺ Channels in Canine Heart Failure. Jia-Qiang He, Ravi C. Balijepalli, Robert A. Haworth, Timothy J. Kamp (Circ Res. Proof Copy, September 25, 2005)

Oct. 13, 2005
Kurt W. Saupe, Ph.D., Assistant Professor, Medicine (Cardiovascular) and Physiology.

Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. A. Miranville, MSc; C. Heeschen, MD; C. Sengenès, PhD; C.A. Curat, PhD; R. Busse, MD, PhD; A. Bouloumié, Ph.D. Circulation. 2004 Jul 20;110(3):349-55. Epub 2004 Jul 6.

Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. V. Planat-Bénard, C. Menard, M. André, M. Puceat, A. Perez, J.-M. Garcia-Verdugo, L. Pénicaud, L. Casteilla Circ Res. 2004 Feb 6;94(2):223-9. Epub 2003 Dec 1.

Nov. 10, 2005
Michele Jaeger, Graduate Student, CMB; Trainee, Training Program in Translational Cardiovascular Science

Dystrophic heart failure blocked by membrane sealant poloxamer. Soichiro Yasuda, DeWayne Townsend, Daniel E. Michele, Elizabeth G. Favre, Sharlene M. Day & Joseph M. Metzger. Nature. 2005 Aug 18;436(7053):1025-9

Dec. 8, 2005
Carl W. Tong, MD, Ph.D., Medicine, Postdoctoral Trainee, Training Program in Translational Cardiovascular Science

b-Blockers Restore Calcium Release Channel Function and Improve Cardiac Muscle Performance in Human Heart Failure. Steven Reiken, PhD; Xander H.T. Wehrens, MD, PhD; John A. Vest, MD; Alessandro Barbone, MD; Stefan Klotz, MD; Donna Mancini, MD; Daniel Burkhoff, MD; Andrew R. Marks, MD. Circulation. 2003;107:2459-2466.

Spring 2006

Jan. 12, 2006
Jennifer E. Grant, Ph.D., Physiology, Postdoctoral Trainee, Training Program in Translational Cardiovascular Science

Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) and Electrospray (ESI) mass spectrometric methods add a new technology to the protein chemist's armamentarium. I have chosen two papers (Kobayashi et al and Haworth et al) from the literature that reflect progress made defining phosphorylation sites within troponin I- phosphorylation sites that may contribute to cardiac hypertrophy and the progression to heart failure. The purpose of this topic-driven journal club is: 1. to review the progress made in defining troponin I phosphorylation events, 2. to evaluate the strengths and limitations of the MALDI-TOF and electrospray methods currently being employed to study cardiac contractile regulatory proteins and 3. to understand the direction that proteomic analysis of cardiac contractile proteins is likely to take.

Protein Kinase D Is a Novel Mediator of Cardiac Troponin I Phosphorylation and Regulates Myofilament Function Robert S. Haworth, Friederike Cuello, Todd J. Herron, Gereon Franzen, Jonathan C. Kentish, Mathias Gautel, Metin Avkiran Circ. Res. 2004; 95; 1091-1099

A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: Identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C Tomoyoshi Kobayashi, XiaofengYang, Lori A.Walker, Richard B.Van Breemen, R. John Solaro. Journal of Molecular and Cellular Cardiology 38 (2005) 213–218

Feb. 9, 2006
Stacey Brickson, Ph.D., Postdoctoral Trainee, Training Program in Translational Cardiovascular Science.
and Julian Stelzer, Ph.D., Physiology, Postdoctoral Fellow.

Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function Sakthivel Sadayappan, James Gulick, Hanna Osinska, Lisa A. Martin, Harvey S. Hahn, Gerald W. Dorn II, Raisa Klevitsky, Christine E. Seidman, Jonathan G. Seidman, Jeffrey Robbins Circ Res. 2005; 97:1156-1163

Mar. 9, 2006
Robert A. Haworth, Ph.D., Distinguished Scientist, Surgery

Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy, Minhas KM, Saraiva RM, Schuleri KH, Lehrke S, Zheng M, Saliaris AP, Berry CE, Vandegaer KM, Li D, Hare JM Circ Res. 2006 Feb 3;98(2):271-9

Apr. 13, 2006
James M. Ervasti, Ph.D., Professor, Physiology

Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells Navaline L. Quach, Thomas A. Rando. Developmental Biology xx (2006) xxx–xxx (Article in Press) Received for publication 12 August 2005; accepted 14 December 2005

May 11, 2006
Eric Schmuck, Graduate Student, Physiology

Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction Yoshinori Miyahara, Noritoshi Nagaya, Masaharu Kataoka, Bobby Yanagawa, Koichi Tanaka, Hiroyuki Hao, Kozo Ishino, Hideyuki Ishida, Tatsuya Shimizu, Kenji Kangawa, Shunji Sano, Teruo Okano, Soichiro Kitamura & Hidezo Mori Nature Medicine Apr 2006; 12(4): 459-4

Click here for the 2004-2005 schedule
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Click here for the 2002-2003 schedule
Click here for the 2001-2002 schedule