Arrhythmias/Ion Channels Journal Club Schedule
(2007-2008)

Fourth Thursdays, 11 AM - 12:30 PM
Room 116 Service Memorial Institute
1300 University Avenue
Jonathan C. Makielski, MD, Professor, Cardiovascular Medicine, Chair
Contact info@cvrc.wisc.edu or 263-2266 for further information

Fall 2007

Sep. 27, 2007
Bin Ye, Ph.D. Assistant Scientist, Cellular and Molecular Arrhythmia Research Program

Novel Approaches for Gene-Specific Interference Via Manipulating Actions of MicroRNAs: Examination on the Pacemaker Channel Genes HCN2 and HCN4 Jiening Xiao, Baofeng Yang, Huixian Lin, Yanjie Lu, Xiaobin Luo and Zhiguo Wang  J. Cell. Physiol. 212: 285–292, 2007.

Oct. 25, 2007
Amanda Vega, Graduate Student, Physiology, and Trainee, Training Program in Translational Cardiovascular Science

Impaired interaction between the slide helix and the C-terminus of Kir2.1: A novel mechanism of Andersen syndrome  Niels Decher, Vijay Renigunta, Marylou Zuzarte, Malle Soom, Stefan H. Heinemann, Katherine W. Timothy, Mark T. Keating, Jürgen Daut, Michael C. Sanguinetti, Igor Splawski  Cardiovascular Research 75 (2007) 748–757.

Nov. 15, 2007 (one week early due to holiday)
Jabe Best, Graduate Student, Molecular and Cellular Pharmacology, and Trainee, Training Program in Translational Cardiovascular Science

Dominant Negative Suppression of Rad Leads to QT Prolongation and Causes Ventricular Arrhythmias via Modulation of L-type Ca2_ Channels in the Heart Hirotaka Yada, Mitsushige Murata, Kouji Shimoda, Shinsuke Yuasa, Haruko Kawaguchi, Masaki Ieda, Takeshi Adachi, Mitsuru Murata, Satoshi Ogawa, Keiichi Fukuda Circ Res. 2007;101:69-77.

Dec. 20, 2007 (one week early due to Christmas holiday)
Jonathan C. Makielski, MD, Professor, Cardiovascular Medicine, Director, Training Program in Translational Cardiovascular Science

Mutation in Glycerol-3-Phosphate Dehydrogenase 1–Like Gene (GPD1-L) Decreases Cardiac Na_ Current and Causes Inherited Arrhythmias Barry London, MD, PhD; Michael Michalec, MS; Haider Mehdi, PhD; Xiaodong Zhu, PhD; Laurie Kerchner, BS; Shamarendra Sanyal, PhD; Prakash C. Viswanathan, PhD; Arnold E. Pfahnl, MD, PhD; Lijuan L. Shang, PhD; Mohan Madhusudanan, MD; Catherine J. Baty, PhD; Stephen Lagana, BA; Ryan Aleong, MD; Rebecca Gutmann, RN, BSN; Michael J. Ackerman, MD, PhD; Dennis M. McNamara, MD; Raul Weiss, MD; Samuel C. Dudley Jr, MD, Ph.D. Circulation 2007;116;2260-2268

Molecular and Functional Characterization of Novel Glycerol-3-Phosphate Dehydrogenase 1–Like Gene (GPD1-L) Mutations in Sudden Infant Death Syndrome David W. Van Norstrand, BS; Carmen R. Valdivia, MD; David J. Tester, BS; Kazuo Ueda, MD, PhD; Barry London, MD, PhD; Jonathan C. Makielski, MD; Michael J. Ackerman, MD, Ph.D. Circulation 2007;116;2253-2259

Spring 2008

Jan. 24, 2008
Sadguna Balijepalli, Ph.D., Research Associate, Cellular and Molecular Arrhythmia Research Program

An essential role for cortactin in the modulation of the potassium channel Kv1.2 Michael R. Williams, Jonathan C. Markey, Megan A. Doczi, and Anthony D. Morielli. PNAS 2007; 104 (44) 17412–17417

Feb. 28, 2008
Carmen Valdivia, MD, Senior Scientist, Cellular and Molecular Arrhythmia Research Program

Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes,  Daniel R. Gonzalez, Farideh Beigi, Adriana V. Treuer, and Joshua M. Hare PNAS 2007; 104 (51) 20612-20617 2007

Mar. 27, 2008
Katie Holzem, Research Specialist, Cellular and Molecular Arrhythmia Research Program

Zebrafish model for human long QT syndrome Rima Arnaout, Tania Ferrer, Jan Huisken, Kenneth Spitzer, Didier Y. R. Stainier, Martin Tristani-Firouzi, and Neil C. Chi PNAS Vol 104:27, 11316–11321

May 22, 2008
Nian-Qing Shi, Ph.D., Assistant Scientist, Cellular and Molecular Arrhythmia Research Program

Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism Pierre Philip-Couderc, Nadia Isidoro Tavares, Angela Roatti, Rene´ Lerch, Christophe Montessuit, Alex J. Baertschi, Circ Res. 2008;102:e20-e35; originally published online Jan 17, 2008

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