James H. Stein, M.D.

Director, UW AIRP

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Jim SteinJames H. Stein, MD is a Professor of Medicine in the Division of Cardiovascular Medicine at the University of Wisconsin School of Medicine and Public Health in Madison, Wisconsin. He is Director of the Preventive Cardiology Program and Director of the Vascular Health Screening Program at the University of Wisconsin Hospital and Clinics. He also is Associate Director of the Adult Echocardiography Laboratory.

Background

Dr. Stein received his baccalaureate degree with honors from the University of Wisconsin. He received his Doctor of Medicine (cum laude) degree from the Yale University School of Medicine in New Haven, Connecticut. His Internship and Residency in Internal Medicine were at the University of Chicago Medical Center in Illinois. He completed a Cardiology Fellowship at Rush-Presbyterian-St. Luke's Medical Center in Chicago, Illinois.

Dr. Stein was elected to Alpha Omega Alpha in medical school. He has received several awards for excellence in teaching from the medical students and residents at the University of Chicago Medical Center and University of Wisconsin Hospital and Clinics. He received the American College of Cardiology W. Proctor Harvey Young Teacher Award for Excellence in Teaching in 2001. Dr. Stein has been named one of Madison's "Top Docs" in Cardiology by Madison Magazine since 2000. In 2007, he was named one of the 20 best cardiologists in America by Men's Health Magazine. In 2008, he was named one of the 20 best cardiologists in America by Women's Health Magazine.

He is a Diplomate of the American Board of Internal Medicine in Internal Medicine and Cardiovascular Diseases. He is a Diplomate of the American Board of Echocardiography in Comprehensive Adult Echocardiography and a Fellow of the American College of Cardiology, the American Heart Association, the American Society of Echocardiography, and the American College of Physicians.

He was Co-Chairman of the 2006 American College of Cardiology Annual Scientific Sessions and is a member of the American College of Cardiology Clinical Expert and Consensus Documents Task Force. Dr. Stein was a Guest Expert and Participant in the American College of Cardiology 34th Bethesda Conference: “Can Atherosclerosis Imaging Improve the Detection of Patients at Risk for Ischemic Heart Disease?” and was a co-author of the American Society of Echocardiography Recommendations for Use of Echocardiography in Clinical Trials. He currently is Chairman of the American Society of Echocardiography Carotid IMT Writing Group and their Consensus Statement on "Use of Carotid Ultrasound to Identify Subclinical Vascular Disease and Evaluate Cardiovascular Disease Risk." Dr. Stein is Chairman of the HIV Medical Association/Infectious Disease Society of America Guidelines Committee for the Evaluation and Management of Dyslipidemia in HIV-Infected Adults Receiving Antiretroviral Therapy. He is on the Steering Committees and Data Monitoring Committees for several multi-center studies. He also is an ad hoc reviewer for the NIH.

Research Interests

Dr. Stein is Director of the UW AIRP. His research interests include ultrasound assessment of atherosclerosis, endothelial function, and clinical trials in preventive cardiology. Specific interests include the detection and characterization of subclinical atherosclerosis using CIMT and UBART in individuals with diabetes mellitus, sleep apnea, tobacco use, and human immunodeficiency virus (HIV), and the use of CIMT measurements for determination of "vascular age" and cardiovascular risk prediction. Dr. Stein has directed the core brachial artery ultrasound laboratory for several single and multicenter trials studying the effects of statins, antiretroviral therapy, smoking cessation interventions, estrogen replacement therapy, and nutritional supplements on endothelial function.


Representative Publications

  1. Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999; 100:1050-1055.
  2. Stein JH, Klein MA, Bellehumeur JL, Aeschlimann SE, McBride PE, Sosman JM. Use of human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunction. Circulation 2001; 104:257-262.
  3. Chou EJ, Keevil JG, Aeschlimann SE, Wiebe DA, Folts JD, Stein JH. Effect of ingestion of purple grape juice on endothelial function in patients with coronary artery disease. American Journal of Cardiology 2001; 88:553-555.
  4. Stein JH, Carlsson CM, Papcke-Benson K, Aeschlimann SE, Bodemer A, Carnes ML, McBride PE. The effects of lipid-lowering and antioxidant vitamin therapies on endothelial function in older adults with hypercholesterolemia. Journal of the American College of Cardiology 2001; 38:1806-1813.
  5. Chuang ML, Douglas PS, Bisinov EA, Stein JH. Effect of cardiac cycle on ultrasound assessment of endothelial function. Vascular Medicine 2002; 7:103-108.
  6. Stein JH, Merwood MA, Bellehumeur JL, Aeschlimann SE, Korcarz CE, Underbakke GL, Mays ME, Sosman JM. The effects of pravastatin on atherogenic lipoproteins and endothelial function in patients with human immunodeficiency virus. American Heart Journal 2004; 147:e18:1-7.
  7. Stein JH. Carotid intima-media thickness and vascular age: You are only as old as your arteries look. Journal of the American Society of Echocardiography 2004; 17:686-689.
  8. Korcarz CE, Stein JH. Transthoracic assessment of coronary flow reserve: Technical considerations. Journal of the American Society of Echocardiography 2004; 17:704-707.
  9. Stein JH, Fraizer MC, Aeschlimann SE, Nelson-Worel J, McBride PE, Douglas PS. Vascular age: Integrating carotid intima-media thickness measurements with global coronary risk assessment. Clinical Cardiology 2004; 27:388-392.
  10. Carlsson CM, Pharo LM, Aeschlimann SE, Mitchell C, Underbakke G, Stein JH. Effects of multivitamins and low-dose folic acid supplements on plasma homocysteine levels and flow-mediated vasodilation in older adults. American Heart Journal 2004; 148:e11:1-8.
  11. Stein JH, Douglas PS, Srinivasan SR, Bond MG, Tang R, Li S, Chen W, Berenson GS. Distribution and cross-sectional age-related increases of carotid artery intima-media thickness in young adults: The Bogalusa Heart Study. Stroke 2004; 12:2782-2787.
  12. Stein JH, Merwood MA, Bellehumeur JB, McBride PE, Wiebe DA, Sosman JM. Postprandial lipoprotein changes in patients taking antiretroviral therapy for human immunodeficiency virus infection. Arteriosclerosis, Thrombosis, and Vascular Biology 2005; 25:399-405.
  13. Stein JH, Korcarz CE, Mays ME, Douglas PS, Palta M, Zhang H, LeCaire T, Paine D, Gustafson D, Fan L. A semi-automated border detection program that facilitates clinical use of ultrasound carotid intima-media thickness measurements. Journal of the American Society of Echocardiography 2005; 18:244-251.
  14. Tzou WS, Douglas PS, Srinivasan SR, Chen W, Berenson G, Stein JH. Advanced lipoprotein testing does not improve identification of subclinical atherosclerosis in young adults: The Bogalusa Heart Study.  Annals of Internal Medicine 2005; 142:742-750.
  15. Tzou WS, Douglas PS, Srinivasan SR, Bond G, Tang R, Chen W, Berenson G, Stein JH. Increased subclinical atherosclerosis in young adults with metabolic syndrome: The Bogalusa Heart Study. Journal of the American College of Cardiology 2005; 46:457-463.
  16. Wyman RA, Fraizer MC, Keevil JG, Busse KL, Aeschlimann SE, Korcarz CE, Stein JH. Ultrasound-detected carotid plaque as a screening tool for advanced subclinical atherosclerosis. American Heart Journal 2005; 150:1081-1085.
  17. Tzou WS, Korcarz CE, Mays ME, Aeschlimann SE, Stein JH. Skin cholesterol content identifies increased carotid intima-media thickness in asymptomatic adults. American Heart Journal 2005; 150:1135-1139.
  18. Gepner AG, Korcarz CE, Aeschlimann SE, LeCaire TJ, Palta M, Tzou WS, Stein JH. Validation of a carotid intima-media thickness border detection program for use in an office setting. Journal of the American Society of Echocardiography 2006; 19:223-228.
  19. Wyman RA, Keevil JG, Busse KL, Aeschlimann SE, Korcarz CE, Stein JH. Is the ankle-brachial index a useful screening test for subclinical atherosclerosis in asymptomatic, middle-aged adults? Wisconsin Medical Journal 2006; 105:50-54.
  20. Gepner AD, Keevil JG, Wyman RA, Aeschlimann SE, Korcarz CE, Busse KL, Stein JH. Use of carotid intima-media thickness and "vascular age" to modify cardiovascular risk prediction. Journal of the American Society of Echocardiography 2006; 19:1170-1174.
  21. Tzou WS, Korcarz CE, Aeschlimann SE, Stein JH. Use of handheld ultrasound by a non-sonographer clinician to measure carotid intima-media thickness. Journal of the American Society of Echocardiography 2006; 19:1286-1292.
  22. Johnson HM, Douglas PS, Srinivasan SR, Bond MG, Tang R, Li S, Chen W, Berenson GS, Stein JH. Predictors of carotid intima-media thickness progression in young men and women: The Bogalusa Heart Study. Stroke 2007; 38:900-905.
  23. Keevil JG, Cullen MW, Gangnon R, McBride PE, Stein JH. Implications of the United States' Cardiac Risk and LDL Cholesterol Distributions for the Diagnosis and Treatment of Dyslipidemia: Data from NHANES 1999 - 2002. Circulation 2007; 115:1363-1370.
  24. Tzou WS, Korcarz CE, Aeschlimann SE, Morgan BJ, Skatrud JB, Stein JH. Coronary flow velocity changes in response to hypercapnia: Assessment by transthoracic Doppler echocardiography. Journal of the American Society of Echocardiography 2007; 20:421-426.
  25. Tzou WS, Douglas PS, Srinivasan SR, Bond MG, Tang R, Chen W, Berenson GS, Stein JH. Distribution and predictors of carotid artery intima-media thickness in young adults: The Bogalusa Heart Study. Preventive Cardiology 2007; 10:181-189.
  26. Gepner AD, Wyman RA, Korcarz CE, Aeschlimann SA, Stein JH. An abbreviated carotid intima-media thickness scanning protocol to facilitate clinical screening for subclinical atherosclerosis. Journal of the American Society of Echocardiography 2007; 20:1269-1275.
  27. Wyman RA, Gimelli G, McBride PE, Korcarz CE, Stein JH. Does detection of carotid plaque affect physician behavior or motivate patients? American Heart Journal 2007; 154:1072-1077.
  28. Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, Najjar S, Rembold CM, Post WS. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Journal of the American Society of Echocardiography 2008; 21:93-111.
  29. Korcarz CE, Hirsch AT, Bruce C, DeCara JM, Mohler ER, Pogue B, Postley J, Tzou WS, Stein JH. Carotid intima-media thickness testing by non-sonographer clinicians: The Office Practice Assessment of Carotid Atherosclerosis (OPACA) Study. Journal of the American Society of Echocardiography 2008; 21:117-122.
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Last updated December 23, 2008